2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide
4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9
CAS: 1282512-48-4
Molecular Formula: C24H28N8O2
2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide - Names and Identifiers
2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide - Physico-chemical Properties
| Molecular Formula | C24H28N8O2 |
| Molar Mass | 460.53 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Boling Point | 783.3±70.0 °C(Predicted) |
| pKa | 15.54±0.50(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | GDC-0032 is an orally biopotent, selective inhibitor of the type I PI3Kα,δ, and γ subtypes, inhibiting the PI3Kβ subtype is 30 times less effective than inhibiting the PI3Kα subtype. Pre-clinical data indicate increased activity GDC-0032 against PI3Kα isoform (PIK3CA) mutant and HER2 amplified tumor cell lines. GDC-0032 inhibit MCF7-neo/HER2 cell proliferation with an IC50 of 2.5 nM. |
| In vivo study | GDC-0032 pharmacokinetics were dose proportional and time independent, with an average t 1/2 of 40 hours. The combination of GDC-0032 with Fulvestrant, which enhanced Fulvestrant activity, resulted in tumor regression and delayed tumor growth (tumor growth inhibition (TGI) of 91%). In addition, GDC-0032 was combined with Tamoxifen to enhance the efficacy of Tamoxifen in vivo (TGI of the GDC-0032 was 102 percent). |
2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.171 ml | 10.857 ml | 21.714 ml |
| 5 mM | 0.434 ml | 2.171 ml | 4.343 ml |
| 10 mM | 0.217 ml | 1.086 ml | 2.171 ml |
| 5 mM | 0.043 ml | 0.217 ml | 0.434 ml |
Last Update：2024-01-02 23:10:35
![2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide](http://res.chembk.com/assets/str/2d/1/12/1282512-48-4.png)
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Product Name: 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9 Visit Supplier Webpage Request for quotationCAS: 1282512-48-4
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